Genome-wide resolution of the reactive oxygen species detoxification machinery of anaerobic ammonium oxidizing bacteria

Title

Genome-wide resolution of the reactive oxygen species detoxification machinery of anaerobic ammonium oxidizing bacteria

Speaker

Xiaotang Cui (2^nd year MSc Student in CEE)

Supervisor

Assoc. Prof. Alex Furman (Technion, CEE) and Assoc. Prof. Xiaowu Huang (GTIIT, ESE) 

Time and Location

Sunday, September 15 2024, 16:00-17:00 (China time) or 11:00-12:00 (Israel time), R202, North Campus

Zoom Meeting

https://gtiit.zoom.us/j/8129031250?omn=94240843895

Abstract

This study intends to explore the reactive oxygen species (ROS) detoxification machineries of anammox bacteria, previously recognized as strict anaerobes, through comparative genomic approaches. A high-resolution alignment of anammox bacterial genomes and ROS scavenging enzymes was conducted to underpin the well-known ROS detoxification mechanisms of anammox bacteria and explore uncharted ROS detoxification pathways. Our preliminary results indicated that multi ROS scavenging enzymes were prevalent in Brocadia, Scalindua and Kuenenia. Besides, a genome-scale metabolic network (GSMN) platform will be built to better explore the metabolic mechanisms and functional capacity of anammox bacteria. This study offers insights into the anti-oxidative defense mechanisms of anammox bacteria, leading to in-depth understandings of their survival niche in aerophilic ecosystems and artificial systems.