{"id":943,"date":"2023-09-03T09:39:45","date_gmt":"2023-09-03T09:39:45","guid":{"rendered":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/?page_id=943"},"modified":"2023-09-12T06:17:50","modified_gmt":"2023-09-12T06:17:50","slug":"5-acquisition-of-mechanistic-insights-into-the-attenuation","status":"publish","type":"page","link":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/5-acquisition-of-mechanistic-insights-into-the-attenuation\/","title":{"rendered":"(5) Acquisition of mechanistic insights into the attenuation"},"content":{"rendered":"\t\t
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(5) Acquisition of mechanistic insights into the attenuation of amyloid curli biogenesis in Salmonella biofilm by drug repurposing strategy (funded by NSFC RFIS-I project).<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Salmonella is an important foodborne pathogen that causes gastroenteritis and systemic infection. Despite advancements in antibiotic therapy, Salmonellosis is still a substantial public health concern. Salmonella utilizes biofilm as a virulence strategy to survive in host and stress conditions and Salmonella outbreaks are mainly attributed to biofilms. Moreover, biofilm has a critical role in antibiotic interventions and promotes multidrug resistance. Given the convincing evidence of damage that arises as a result of Salmonella biofilm, there is an urgent need for anti-biofilm agents to improve clinical outcomes. Salmonella produces an extracellular matrix comprised of functional amyloid curli fibres and cellulose during biofilm development. Curli-specific gene (csg) operons such as csgBA and csgDEFG operon are involved in curli production. Curli represents an excellent target for developing the anti-biofilm drugs in Salmonella. Drug repurposing is a promising approach that can be utilized to identify new anti-biofilm agents. In this project, High-throughput cell-based screening (HTS) strategy will be utilized to identify drugs\/compounds that inhibit amyloid curli biogenesis in Salmonella. Further, the mechanism of action of anti-biofilm effects of potential hits at the molecular level will be studied. Moreover, a gallstone mice model will be used to study the effects of potential hit(s) to inhibit Salmonella biofilm in <\/span>vivo<\/i><\/span>.<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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(5) Acquisition of mechanistic insights into the attenuation of amyloid curli biogenesis in Salmonella biofilm by drug repurposing strategy (funded by NSFC RFIS-I project). Salmonella is an important foodborne pathogen that causes gastroenteritis and systemic infection. Despite advancements in antibiotic… Read More<\/a><\/p>\n","protected":false},"author":341,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":[],"_links":{"self":[{"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/pages\/943"}],"collection":[{"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/users\/341"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/comments?post=943"}],"version-history":[{"count":3,"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/pages\/943\/revisions"}],"predecessor-version":[{"id":1092,"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/pages\/943\/revisions\/1092"}],"wp:attachment":[{"href":"https:\/\/sites.gtiit.edu.cn\/foodinnovationgroup\/wp-json\/wp\/v2\/media?parent=943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}