The Agilent 6470B triple quadrupole MS coupled with 1290 Infinity II LC employs several technological advantages like the superheated Agilent Jet Stream (AJS) ion source, curved and tapered collision cell, heated hyperbolic quadrupoles, and ± 20 kV high-energy dynode detector system. The 6470B LC/TQ also features instrument intelligence technologies such as early maintenance feedback, scheduled tune and check-tune, and intelligent secondary injection workflows. Wide mass range allows the analysis of ions of various classes and sizes, from small molecules to multiply charged peptides.