Major Research Program on Spatiotemporal Network Regulation of Glycolipid Metabolism Program Guidelines for FY2023
- Scientific Objectives
Taking the spatio-temporal network regulation of glycolipid metabolism as the core of research, we will reveal the perception and response mode of the organism, organs, cells and subcellular structures to the state of glycolipid metabolism; analyze the information dialogue and collaborative regulation network among tissues and organs regulating the metabolic homeostasis; find out the pathways and regulation mechanisms of the production, transport and transformation of important glycolipid metabolites; discover the new laws of the glycolipid metabolism regulation and the maintenance of the homeostasis; elucidate the roles of the metabolism changes in The role of spatial and temporal changes in metabolism in environmental adaptation and health; reveal the core mechanism of metabolic homeostasis in the development of diseases, and develop new strategies for metabolic health.
2.Core Scientific Issues
The core mechanism of glucose and lipid metabolism, spatial and temporal network regulation, and its changing law under physiological and pathological conditions.
3.Research Direction for 2023
This year, we will carry out the funding work in the form of “integrated project”, and encourage the project leaders who have made good progress in the research of glycolipid metabolism in the previous period to jointly apply for the project. Based on the innovative results achieved in the previous years, and taking into account the research progress and development trend of related fields at home and abroad, we will carry out integrated projects in the following research directions this year.
(1) Glucose metabolism signal perception mechanism and biological effects.
Focusing on the biological functions of glucose and its metabolites under specific physiological and stress conditions, we will focus on the mechanism of glucose and its metabolites as signaling molecules, the signaling process and biological functions.
(2) Lipid metabolism signaling mechanism and biological effects.
We will focus on the key pathways and regulatory nodes of lipid metabolism, study the regulatory effects of different nutrients on lipid metabolism, reveal the important metabolites in lipid metabolism that have signaling effects and their sensing mechanisms, and analyze the physiological and pathological functions.
(3) Organelle Interaction in Glycolipid Metabolism.
Focusing on mitochondria, endoplasmic reticulum, lipid droplets and other key organelles in glycolipid synthesis and catabolism, we will reveal the dynamic changes and molecular mechanisms of organelle interactions in glycolipid synthesis and catabolism, and analyze the physiological and pathological functions of key regulatory factors.
(4) Regulation of glycolipid metabolism by novel hormones.
Focusing on the maintenance of metabolic homeostasis, we will discover and identify new types of hormones and receptors that regulate glycolipid metabolism, and reveal their physiological and pathological functions, mechanisms of action, signaling pathways, and functions in cross-tissue and organ dialogue.
(5) Neural regulation of glycolipid metabolism.
Focusing on the role of neural regulation of glycolipid homeostasis, we will reveal the principle of brain regulation of glycolipid metabolism homeostasis through direct sensing of nutrients, as well as the mechanism of neural regulation of peripheral energy storage and consumption at different developmental stages by the nerves themselves or via the autonomic nervous system.
(6) Effects of microbial-host interactions on glycolipid homeostasis.
Focusing on the interactions of metabolites and metabolic enzymes of intestinal microorganisms with intestinal tissues and important metabolic organs, we will identify the key nodes and regulatory mechanisms affecting the balance of glucose-lipid metabolism homeostasis, and reveal the roles of microorganisms in pathophysiological processes, such as imbalance of glucose-lipid metabolism.
(7) Glycolipid metabolism reprogramming in tumors.
Focusing on the unrestricted proliferation ability of tumor cells, which distinguishes them from normal cells, we will analyze the new mechanism of glycolipid metabolism reprogramming that promotes the cell cycle process.
(8) Transgenerational regulation of glycolipid metabolism.
Focus on the role of parental non-classical genetic factors in the regulation of glycolipid homeostasis in offspring, and discover their sources, transgenerational transmission modes, target organs and mechanisms.
(9) Glycolipid metabolism imbalance and intervention strategies.
To study the imbalance of glycolipid metabolism through systematic quantitative characterization, to reveal the panoramic maps of glycolipid metabolism at different stages of disease development, and to carry out clinical (pre)intervention studies of metabolic diseases to help precise diagnosis and treatment.
(10) Metabolite subcellular fine localization analysis and high-resolution mapping.
Comprehensive high spatial and temporal resolution and high coverage metabolite identification, sensing and quantitative methods, in-situ quantitative analysis of the distribution and dynamics of important glycolipid metabolites in subcellular structures, development of original technologies, tools and algorithms, and construction of metabolite subcellular spatial and temporal dynamics of high-resolution mapping.
- 2023 Funding Program
Eight integrated projects will be funded for a period of three years, with a direct cost intensity of about 8 million RMB/project, and the research period should be “January 1, 2024-December 31, 2026” in the application form.
- Application Requirements and Notes
(1) Application requirements.
Applicants for this major research program shall have the following conditions:
1. experience in undertaking basic research projects;
2. have senior professional and technical positions (titles).
Postdoctoral researchers on station, those who are pursuing postgraduate degrees and those who have no work unit or whose units are not the supporting units shall not be allowed to apply as applicants.
(2) Regulations on limited applications.
Enforce the requirements of the “Application Regulations” in the “2023 NSF Program Guidelines”. The applicants and key participants of the integrated projects of major research programs are not subject to the total number of projects applied for and undertaken.
(3) Application Notes.
Applicants and supporting organizations should carefully read and implement the relevant requirements in this Program Guide, the NSF Program Guide for FY2023, and the Notice on Matters Related to the Application and Completion of NSF Programs for FY2023.
- Paperless application is implemented for this major research program project. The date of application submission is from October 26, 2023 to November 1, 2023 at 16:00.
(1) Applicants shall fill in and submit the electronic application form and attached materials online in accordance with the Instructions and Outline for Major Research Programs in the Web-based Information System of the Science Foundation (hereinafter referred to as the Information System).
(2) The purpose of this Major Research Program is to closely focus on the core scientific problems and to form an integrated project group through strategic and advantageous integration of multiple disciplines. Applicants shall formulate their own project titles, scientific objectives, research contents, technical routes and corresponding research funding according to the specific scientific problems to be solved by this Major Research Program and the funded research directions announced in the Program Guidelines.
(3) In the application form, select “Major Research Program” for the funding category, “Integrated Project” for the subcategory description, “Regulation of Spatial and Temporal Networks of Glycolipid Metabolism” for the note description, and select the corresponding research title according to the specific research content of the application. Select the corresponding application code according to the specific research content of the application.
The number of collaborating research units for the integrated project must not exceed 4. The main participants of the integrated project must be the actual contributors of the project, and the total number of participants should not exceed 9.
(4) The applicant shall, in the “Basis and Research Content” section of the application form, firstly state that the application is in line with the funded research directions in the Guidelines for this project and indicate the name of the corresponding research direction, and at the same time explain the contribution of the applied-for project to solving the core scientific problems and realizing the scientific objectives of this major research program.
If the applicant has undertaken other science and technology projects related to this Major Research Program, the applicant shall discuss the difference and connection between the applied project and other related projects in the “Research Basis and Working Conditions” part of the application. 2.
- The supporting unit shall complete the work of commitment of the supporting unit, organization of the application and examination of the application materials in accordance with the requirements. They should confirm the submission of the electronic application form and attached materials item by item through the information system before 16:00 on November 1, 2023, and submit the list of project applications online before 16:00 on November 2, 2023.
- Other notes.
(1) In order to realize the overall scientific objectives and multidisciplinary integration of the Major Research Program, the project leaders of the funded projects should undertake to comply with the regulations on the management and sharing of relevant data and information, and to support the work related to big data carried out at the level of the Major Research Program, and should pay attention to the mutual supportive relationship with other projects of the Major Research Program in the course of the implementation of the projects.
(2) In order to strengthen the academic exchanges of the projects, and to promote the formation of project clusters and multidisciplinary crossover and integration, this Major Research Program will hold an annual academic exchange meeting of the funded projects once a year, and will organize academic seminars in related fields from time to time. The person in charge of the funded projects is obliged to participate in the above academic exchange activities organized by the Steering Expert Group and the Management Working Group of this Major Research Program.
4.Consultation Methods.
Biology Division II, Department of Life Sciences, National Natural Science Foundation of China (NSFC)
Tel: 010-62329253