Osmium(VI) Nitrido Complexes as Potential Anticancer Agents

Title

Osmium(VI) Nitrido Complexes as Potential Anticancer Agents

Speaker

Prof. Wenxiu Ni 倪文秀 (Shantou University Medical College 汕头大学医学院)

Host

Prof. Kai Huang (GTIIT, Chemistry)

Time and Location

May. 26 2022, Thursday, 11:00am-12:00pm(China Time),  E502 (Education Building, 5th floor)

Language

Chinese

Abstract

Over the years, platinum-based anti-cancer drugs such as, cisplatin, carboplatin or oxaliplatin are incredibly important. Approximately 50% chemotherapy patients relied on these drugs for cancer treatments. Unfortunately, there are some rising dose-limiting side-effects and dropping efficacy due to drug resistance. These barriers have emerged the search for other non-platinum-based anti-cancer alternatives. Our group^1-5 have demonstrated that Os^VIºN is a versatile platform for making new anticancer metallodrugs. So far, cytotoxic osmium(VI) nitrides constructed with monodentate, bidentate, tridentate and tetradentate ligands have been reported. Some OsN complexes show similar mechanism to cisplatin in killing cancer cells via apoptosis pathway, presumably the strong N^3– group constitutes a vacant and/or a labile coordination site in osmium for DNA binding. Others were reported non-apoptotic cell death such as autophagy and oncosis. Cancer cell-bearing nude mouse experiments implied good in vivo anti-cancer efficacy of nitrido-osmium complex. Our study paves the way for the development of high-valent osmium complexes as anti-cancer agents.

References

[1] Wen-Xiu Ni, Wai-Lun Man, Myra Ting-Wai Cheung, Raymond Wai-Yin Sun, Yuan-Lan Shu, Yun-Wah Lam,* Chi-Ming Che* and Tai-Chu Lau*. Chem. Commun., 2011, 47, 2140.

[2] Wen-Xiu Ni, Wai-Lun Man, Shek-Man Yiu, Man Ho, Myra Ting-Wai Cheung, Chi-Chiu Ko, Chi-Ming Che, Yun-Wah Lam and Tai-Chu Lau. Chem. Sci.,2012, 3, 1582.

[3] Quan Tang, Wen-Xiu Ni, (Co-first) Chi-Fai Leung, Wai-Lun Man, Kenneth King-Kwan Lau, Yun-Wah Lam, Wai-Yeung Wong, Shie-Ming Peng, Gui-Jian Liu and Tai-Chu Lau. Chem. Commun., 2013, 49, 9980.

[4] Wan-Qiong Huang, Chuan-Xian Wang, Tao Liu, Zi-Xin Li, Chen Pan, Yun-Zhou Chen, Xin Lian, Wai-Lun Man* and Wen-Xiu Ni*. Dalton Trans., 2020, 49, 17173.

[5] Meng Ye, Wan-Qiong Huang, Zi-Xin Li, Chuan-Xian Wang, Tao Liu, YunZhou Chen, Catherine Hong-Huan Hor, Wai-Lun Man* and Wen-Xiu Ni*, Chem. Commun., 2022, 58, 2468.

Biography

Dr. Ni obtained her Ph.D. in Biological Inorganic Chemistry from City University of Hong Kong in 2011. Her Ph.D research focused on metal-based anticancer drug development and discovery under the supervision of Prof. Tai-Chu Lau. From 2012 to 2014, she worked as a postdoc with Prof. Dan Li in Shantou University and carried out research work on the design and photochemical study of luminescent coinage metal complexes as optical functional materials. Dr. Ni joined the Shantou University Medical College as Associate Professor in 2014. Her research interest includes synthesis and mechanism study of new metal-based anticancer agents such as osmium, ruthenium, platinum complexes by using interdisciplinary approaches and methods in the areas of medicinal chemistry, molecular biology, and chemical biology. Dr. Ni has published 20 scientific papers including Journal of the American Chemical Society, Angewandte Chemie International Edition, Chemical Science. She has received an award of the Top Young Talents of Special Support Program of Guangdong Province (2017).