Innate immunity and adaptive immune responses. Antibody classes and sub-classes, structure and function. Genetics and biosynthesis of immunoglobulins. Definitions of isotype allotype, idiotype. Hybridomas. Complement in humoral immunity and inflammation. Antibody based immuno-assays. The Major histocompatibility complex genetics, function and assays. The nature of antigen. The lymphatic system organs, tissues, cells. Genetics and specific of the T-cell receptor. The immune response cells and biological functions. Accessory cells. Cytokines and lymphokines. Inflammation and adhesion molecules. Cellular migration and cell - cell interactions. Natural and acquired tolerance. Autoimmunity, biology of transplantation. Allergies and hypersensitivities. AIDS. Mucosal immunity. Resistance to infection. Immunity of the newborn. The molecular basis of primary immunodeficiencies. Learning outcomes 1. Being familiar with basic immunlogical concepts and terminology. 2. Understanding processes of generation differentiation and activation of immune cells. 3. Understanding the function of the immune system, mechanisms of operation and interactions with other physiological systems. 4. Being able to connect between immune processes and clinical observations.

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